This category collects compounds whose research interest lies in intracellular signalling rather than in a single receptor: mitochondrial-derived peptides acting on…
Read the full description and all 5 compounds →MOTS-c
Sixteen-residue mitochondrial-derived peptide encoded in the 12S rRNA region of mtDNA. Studied in vitro for AMPK-pathway and metabolic-stress signalling.
Also searched as MOTSc · mitochondrial-derived peptide
At a glance
MOTS-c is mitochondrial-derived peptide · 12S rRNA encoded.
- Supplied as
- Lyophilized (freeze-dried) powder in a sealed vial
- Vial sizes
- 10 mg · 40 mg
- Purity
- HPLC-verified, 99% or higher
- Current batch
- 26030503-04, issued March 6, 2026
- Certificate of analysis
- Published in full for this batch
- Ships
- From Texas to all 50 US states
- Intended use
- Laboratory research only. Not for human or veterinary use.
Chemical data
Handling & verification
A sixteen-residue mitochondrial-derived peptide, encoded within mitochondrial DNA rather than nuclear DNA, in the 12S rRNA region. That origin is what makes it of interest as a reference compound in mitochondrial and AMPK-pathway signalling research.
Presentation and storage
Supplied lyophilized in a sealed vial under vacuum. Store the sealed vial at −20 °C for long-term storage; refrigeration at 2–8 °C is adequate over shorter periods. Keep away from light and moisture.
Allow the vial to reach room temperature before opening, so atmospheric moisture does not condense onto the powder.
Reconstitution
Reconstitute with bacteriostatic water. Direct the diluent down the inside wall of the vial rather than onto the powder, and swirl gently — do not shake, as agitation can denature the peptide.
- 10 mg vial in 2 mL diluent gives a 5 mg/mL stock
- 40 mg vial in 4 mL diluent gives a 10 mg/mL stock
- 40 mg vial in 8 mL diluent gives a 5 mg/mL stock
This sequence carries two methionine residues, which oxidise readily, so minimise exposure to air and light once the peptide is in solution.
Once reconstituted, store at 2–8 °C and protect from light. Avoid repeated freeze-thaw cycles — aliquot the stock if it will be drawn on more than a few times.
Verification
Every lot is assayed by HPLC and released at ≥99% purity. The certificate of analysis for the batch currently shipping (26030503-04, released 6 March 2026) is linked above and states the batch number, the assay method and the measured purity.
Common questions
Does MOTS-c come with a certificate of analysis?
Yes. Every lot of MOTS-c ships with its own certificate of analysis showing HPLC purity, and the current certificate is published on our COA page before you buy — you do not have to order first or email anyone to see it.
What purity is MOTS-c?
HPLC-verified at 99% or higher. The certificate for each lot states the measured figure, the detection wavelength and the method used, so the number can be checked rather than taken on trust.
How is MOTS-c supplied and where does it ship?
It is supplied as lyophilized (freeze-dried) powder in a sealed vial, protected against light and impact. Full US shipping, operating from Texas. Delivery estimates are provided by the carrier at checkout.
How should MOTS-c be stored?
Keep the lyophilized vial cold and dark — refrigerated for near-term use, frozen for longer storage. Once reconstituted it belongs in the refrigerator and its usable life is measured in weeks rather than months. Aliquot rather than thawing the same vial repeatedly, because freeze-thaw cycles cost more stability than most people expect.
How do I reconstitute MOTS-c?
Add bacteriostatic water slowly down the inner wall of the vial so the stream does not strike the powder directly, then let it dissolve on its own — swirl gently if needed, never shake. The volume you add sets the concentration, so decide the concentration first and work backwards. Our free reconstitution calculator does that arithmetic and gives the volume to draw per aliquot.
Is MOTS-c for human use?
No. MOTS-c is supplied strictly as a reference material for laboratory research use only. It is not a drug, food, cosmetic or medical device, it is not for human or veterinary consumption, and it is not intended to diagnose, treat, cure or prevent any disease. We do not provide dosing guidance or protocols of any kind.
See the certificate · Reconstitution calculator · All questions
Handling guides
Other compounds
For laboratory and research use only. Not for human or veterinary use, diagnosis, or consumption. Products are sold to qualified researchers and are not drugs, foods, or cosmetics.